By Ming-Ming Zhou
This publication presents a well timed overview of the function of histone adjustments in epigenetic keep watch over of gene expression. subject matters coated comprise: easy mechanisms of molecular popularity of histone post-translational amendment (PTMs); combinatorial readout of histone PTMs through tandem epigenome reader domain names; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their power as a brand new method of healing intervention in human ailments. All chapters have been written by way of best scientists who made the unique key discoveries of the constitution and mechanism of evolutionarily conserved reader domain names, which serve to direct gene transcription in chromatin via interactions with DNA-packing histones in a PTM-sensitive manner.
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Extra info for Histone Recognition
Histone Recognition by Ming-Ming Zhou