By Toshiwo Andoh
In the mid 80's sort I and II enzymes have been came across to be the intracellular ambitions of a few efficacious anticancer medicines resembling doxorubicin, mitoxantrone, etoposide and camptothecin because of a persevered efforts of many investigators, particularly Leroy Liu and his collaborators at Johns Hopkins collage. Readers will discover a sequence of chapters written by means of researchers actively engaged within the increasing box of topoisomerase and their inhibitors. The sequence of chapters conceal evaluation articles on pharmacology and the molecular mechanism of topoisomerase I- and II-targeting anticancer medications in mammals and within the yeast Saccharomyces cerevisiae, which has proved to be an outstanding version organism for reviews of anticancer medicines. This quantity compiles up to date details at the topoisomerase-targeting compounds in medical and preclinical improvement as an invaluable and critical reference booklet for college students and researchers within the box of pharmacology, toxicology, oncology and molecular biology.
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DNA Topoisomerases in Cancer Therapy: Present and Future by Toshiwo Andoh